Response of generalized granuloma annulare to alkylating agents.

摘要: • The conditions of three patients who had generalized granuloma annulare responded favorably to treatment with alkylating agents. This mode therapy in two cases was chosen on the basis recent evidence that implicates delayed hypersensitivity mechanisms as forming part pathogenesis annulare. Two rapid clearing their lesions. response one these observed during for a concomitant plasma cell dyscrasia. third patient an unusual form evolved period 28 years, hand deformities secondary fascial and tendon involvement production contractures lymphedema, which partially therapy. results lend further support data implicating cellular immunity ( Arch Dermatol 114:216-220, 1978)