Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42

作者: John N. Feder , Thomas C. Nelson , Liana M. Lee , Shujian Wu

DOI:

关键词: AntibodyBiochemistryPolynucleotideTestis specificTubulin—tyrosine ligaseRecombinant DNAScreening methodBiology

摘要: The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, recombinant synthetic methods for producing said polypeptides. further relates to diagnostic therapeutic applying these polypeptides the diagnosis, treatment, and/or prevention of various diseases disorders related screening identifying agonists antagonists invention.

参考文章(22)
Piero Carninci, Yoshihide Hayashizaki, High-efficiency full-length cDNA cloning. Methods in Enzymology. ,vol. 303, pp. 19- 44 ,(1999) , 10.1016/S0076-6879(99)03004-9
Isabelle Treilleux, Didier Job, Nadine Peloux, Jürgen Wehland, Robert-Louis Margolis, Laurence Lafanechere, Alain Bremond, Charles Dumontet, Agnes Mialhe, Raoul Payan, Meng-Hong Panh, Tubulin detyrosination is a frequent occurrence in breast cancers of poor prognosis. Cancer Research. ,vol. 61, pp. 5024- 5027 ,(2001)
Nikolaj Blom, Teit E. Johansen, Claus Hansen, Neublastin neurotrophic factors ,(2000)
Valérie Trichet, Myriam Ruault, Gérard Roizès, Albertina De Sario, Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1 Gene. ,vol. 257, pp. 109- 117 ,(2000) , 10.1016/S0378-1119(00)00383-8
Daniel Raybin, Martin Flavin, Enzyme which specifically adds tyrosine to the α chain of tubulin Biochemistry. ,vol. 16, pp. 2189- 2194 ,(1977) , 10.1021/BI00629A023
J. G. Herman, J. R. Graff, S. Myohanen, B. D. Nelkin, S. B. Baylin, Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 9821- 9826 ,(1996) , 10.1073/PNAS.93.18.9821
M F Bonaldo, G Lennon, M B Soares, Normalization and subtraction: two approaches to facilitate gene discovery. Genome Research. ,vol. 6, pp. 791- 806 ,(1996) , 10.1101/GR.6.9.791