Foxo3a regulates apoptosis by negatively targeting miR-21

摘要: MicroRNAs are a class of small non-coding RNAs and participate in the regulation apoptotic program. Although miR-21 is able to inhibit apoptosis, its expression downstream targets remain be fully elucidated. Here we report that transcriptional factor Foxo3a initiates apoptosis by transcriptionally repressing expression. Our results showed doxorubicin could simultaneously induce translocation cell nuclei reduction Knockdown resulted an elevation levels, whereas enforced led decrease In exploring molecular mechanism which regulates miR-21, observed bound promoter region suppressed activity. These indicate can repress searching for found translation Fas ligand (FasL), pro-apoptotic factor. Furthermore, was up-regulate FasL through down-regulating miR-21. data suggest negatively initiating apoptosis.