Involvement of natural killer cells in coxsackievirus B3-induced murine myocarditis.

摘要: The role of natural killer cells in the temporal development coxsackievirus B3-induced myocarditis adolescent CD-1 male mice was examined. Inoculation purified CVB3m induced maximum NK cell activity splenic populations at 3 days postinoculation (p.i.) as assessed by lysis YAC-1 cells; virus titers heart tissues were also found day p.i. Mice depleted after injection anti-asialo GM1 antiserum i.v. had decreased activity, increased tissues, and exacerbated myocarditis. Although lesion number not latter mice, lesions these exhibited myocyte degeneration dystrophic calcification above that inoculated with only. No alteration interferon observed CVB3m-infected treated compared normal mice. Measurements doses 10(2) to 10(8) PFU per mouse or UV-irradiated suggest replication is required for activation. An amyocarditic variant (ts5R) shown replicate elicit comparable elicited CVB3m. Therefore, data activation depends on provide some protection against CVB3m-induced limiting tissues.