作者: M. E. Cooper , T. J. Allen , P. A. Macmillan , B. E. Clarke , G. Jerums
DOI: 10.1007/BF00265552
关键词: Glomerular basement membrane 、 Endocrinology 、 Renal glomerulus 、 Basement membrane 、 Diabetes mellitus 、 Angiotensin-converting enzyme 、 Albuminuria 、 Enalapril 、 Nephropathy 、 Internal medicine 、 Medicine
摘要: This study has evaluated the effects of angiotensin converting enzyme inhibitor Enalapril on glomerular ultrastructure and albuminuria in normotensive hypertensive diabetic rats. Streptozotocin-diabetes was induced Wistar Kyoto spontaneously administered drinking water normotensive, control therapy prevented an increase basement membrane thickness rats without any significant effect fractional mesangial volume. decreased Thus, enalapril retards development thickening rat, presence or absence hypertension.