Enalapril retards glomerular basement membrane thickening and albuminuria in the diabetic rat.

作者: M. E. Cooper , T. J. Allen , P. A. Macmillan , B. E. Clarke , G. Jerums

DOI: 10.1007/BF00265552

关键词: Glomerular basement membraneEndocrinologyRenal glomerulusBasement membraneDiabetes mellitusAngiotensin-converting enzymeAlbuminuriaEnalaprilNephropathyInternal medicineMedicine

摘要: This study has evaluated the effects of angiotensin converting enzyme inhibitor Enalapril on glomerular ultrastructure and albuminuria in normotensive hypertensive diabetic rats. Streptozotocin-diabetes was induced Wistar Kyoto spontaneously administered drinking water normotensive, control therapy prevented an increase basement membrane thickness rats without any significant effect fractional mesangial volume. decreased Thus, enalapril retards development thickening rat, presence or absence hypertension.

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