In vitro activities of new and established triazoles against opportunistic filamentous and dimorphic fungi.
作者： Gloria M. González , Annette W. Fothergill , Deanna A. Sutton , Michael G. Rinaldi , David Loebenberg
DOI: 10.1080/13693780500088416
关键词: Paecilomyces 、 Pseudallescheria boydii 、 Blastomyces dermatitidis 、 Ravuconazole 、 Sporothrix schenckii 、 Dimorphic fungus 、 Coccidioides immitis 、 Fonsecaea pedrosoi 、 Microbiology 、 Biology
摘要: The in vitro activities of three new triazoles were determined and compared to those itraconazole fluconazole against 306 clinical isolates Blastomyces dermatitidis, Cladophialophora carrionii, Coccidioides immitis, Fonsecaea pedrosoi, Fusarium spp., Histoplasma capsulatum, Paecilomyces lilacinus, Pseudallescheria boydii Sporothrix schenckii. Minimum inhibitory concentrations (MIC) by a broth macrodilution method the National Committee for Clinical Laboratory Standards M38-A procedure. Itraconazole (geometric mean MIC, 0.16–0.65 μg/ml), voriconazole 0.18–1.44 ravuconazole 0.18–1.09 posaconazole 0.18–1.38 had relatively uniform values showing potent activity B. C. F. H. S. was variable with strains P. boydii, lilacinus spp.
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