The Lymphotoxin Pathway as a Novel Regulator of Dendritic Cell Function

摘要: Dendritic cells (DC) are critically required for the host response to antigen (Ag) [1, 2]. Upon exposure antigen, DC take up Ag within peripheral tissues and subsequently migrate in chemokine gradients into lymphatics [3]. During this initial Ag, become activated by sensing of microbe-associated molecular patterns (MAMPs) consequently upregulate co-stimulatory molecules such as B7.1 B7.2 so that they may optimally prime Ag-specific CD4+ T [4–6]. leave tissue enter where journey inflamed draining lymph node (LN) [7, 8]. entry LN via subcapsular sinus, “find” rare taking advantage intricate organization itself [9]. Once encounter cells, proliferate. These also concurrently provide signals back Ag-bearing a process has been termed licensing. Licensed can then cross-prime CD8+ T-cell pathogen be cleared. The nature these helper cell-derived their impact on remain poorly elucidated.