Biomembrane models and drug-biomembrane interaction studies: Involvement in drug design and development

摘要: Contact with many different biological membranes goes along the destiny of a drug after its systemic administration. From circulating macrophage cells to vessel endothelium, more complex absorption barriers, interaction biomolecule these largely affects rate and time biodistribution in body at target sites. Therefore, investigating phenomena occurring on cell membranes, as well their drugs physiological or pathological conditions, is important exploit molecular basis diseases identify new potential therapeutic strategies. Of course, complexity structure functions has pushed researchers toward proposition validation simpler two- three-dimensional membrane models, whose utility drawbacks will be discussed. This review also describes analytical methods used look interactions among bioactive compounds particular accent calorimetric techniques. These studies can considered powerful tool for medicinal chemistry pharmaceutical technology, steps designing optimizing activity safety profile already therapy.