Liquid biopsy for breast cancer using extracellular vesicles and cell-free microRNAs as biomarkers.

摘要: Improvement of breast cancer (BC) patient's outcome is directly related to early detection. However, there still a lack reliable biomarkers for diagnosis, prognosis and, treatment follow up in BC, leading researchers study the potential liquid biopsy based on circulating microRNAs (c-miRNAs). These c-miRNAs can be cell-free or associated with extracellular vesicles (EVs), and have great advantages such as stability biofluids, noninvasive accessibility compared current techniques (core-biopsy surgery), expression pathogenic conditions. Recently, new promising field EV-derived miRNAs (EV-miRNAs) has emerged, receiving special attention due their selective vesicle sorting which makes them accurate disease In this review, we discuss findings about c-miRNA BC prognosis, therapy. Additionally, address impact limitations standardization analysis methods implementation these clinical setting.