Dopaminergic Dysfunction in Experimental Hepatic Encephalopathy

摘要: Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that appears as consequence of acute or chronic liver dysfunction. Ammonia considered central to its pathogenesis, but the factors contributing neurological dysfunction disorder entails remain unclear (Butterworth et al., 2002). In humans with HE, it has been suggested basal ganglia may be selectively affected (Spahr 2002), and lesions detected by magnetic resonance in such patients 2000; Burkhard 2003) have associated movement disorders (Layrargues, 2001; Spahr 2002; Weissenborn & Kolbe, 1998). The mechanisms which failure leads abnormal motor function are not clear, symptoms described HE 2002) similar those Parkinson’s disease (PD).