Loading and relaxation dynamics of a red blood cell

摘要: We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subject an external mechanical load. carry out detailed comparison between loading (L) dynamics, following imposition load on RBC at rest, and relaxation (R) allowing relax its original shape after sudden arrest Such is carried by analyzing characteristic times two corresponding i.e., $t_L$ $t_R$. For small intensities load, are symmetrical ($t_L \approx t_R$) independent typology (intrinsic dynamics); in marked contrast, for finite asymmetry found, wherein typically faster than one. This manifests itself with non-universal characteristics, e.g., dependency applied and/or viscoelastic properties membrane. To deepen such behaviour, we consider viscosity erythrocyte membrane as variable parameter focus three different typologies (mechanical stretching, shear flow, elongational flow): this allows clarify how non-universality builds-up terms deformation rotational contributions induced Our results provide crucial quantitative information response imposition/cessation loads.