Synthesis of poly(L-lactide) and polyglycolide by ring-opening polymerization.

摘要: This protocol describes the synthesis of poly(L-lactide) by ring-opening polymerization L-lactide using tin(II) 2-ethylhexanoate catalyst as well polyglycolide glycolide. Ring-opening cyclic diesters synthesized from α-hydroxycarboxylic acids gives high-molecular-weight polyester in high yield. Tin(II) is most common for owing to its reactivity and low toxicity. Purity monomers amount water alcohol reaction system are significant factors increasing molecular weight conversion polyesters. The polyesters also dependent on temperature time. can be completed 3 d 2 polyglycolide.