Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease.

摘要: Numerous reviews have discussed gut microbiota composition changes during inflammatory bowel diseases (IBD), particularly Crohn’s disease (CD). However, most studies address the observed effects by focusing on studying univariate connection between and dietary-induced alterations to composition. The possibility that these may reflect a number of other interconnected (i.e. pantropic) mechanisms, activated in parallel, concerning various bacterial metabolites, is process been elucidated. Progress seems however hampered difficult-to-study factors interacting at mucosal level. Here we highlight some such merit consideration, namely; 1) contribution host genetics diet altering microbiome, turn, crosstalk among secondary metabolic pathways; 2) interdependence amount dietary fat, fatty acid composition, timing route administration community, impact microbiota-derived acids; 3) effect bile modulator role acids microbiota; 4) endogenous exogenous intestinal micronutrients 5) need consider food associated toxins chemicals which can introduce confounding immune modulating elements (e.g., antioxidant phytochemicals oils proteins). These concepts, are not mutually exclusive, herein illustrated paying special emphasis physiologically inter-related processes.