Oxidatively modified proteins in aging and disease1,2 1Guest Editor: Earl Stadtman 2This article is part of a series of reviews on “Oxidatively Modified Proteins in Aging and Disease.” The full list of papers may be found on the homepage of the journal.
作者： M.Flint Beal
DOI: 10.1016/S0891-5849(02)00780-3
关键词: Peroxynitrite 、 Pathogenesis 、 Peroxynitrous acid 、 Amyotrophic lateral sclerosis 、 Disease 、 Oxidative phosphorylation 、 Biochemistry 、 Cancer research 、 Chemistry 、 Oxidative stress 、 Reactive oxygen species 、 Physiology (medical)
摘要: There is a large body of evidence implicating oxidative damage in the pathogenesis both normal aging and neurodegenerative diseases. Oxidative to proteins has been well established. Although there are number potential modifications only few have systematically studied. The most frequently studied marker protein carbonyl groups. 3-Nitrotyrosine thought be relatively specific mediated by peroxynitrite. Increased concentrations carbonyls 3-nitrotyrosine documented as Alzheimer's disease (AD), Parkinson's (PD), amyotrophic lateral sclerosis (ALS). These findings help provide rationale for trials antioxidants
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