Probiotics, prebiotics, and synbiotics for the treatment of asthma: Protocol for a systematic review.

摘要: Background The number of dementia patients in the world is large, and will continue to rise future, which bring a heavy social economic burden. No interventions have been found cure dementia. Medication can delay progression disease impose an Some non-drug therapies often require care caregiver. Probiotics, prebiotics, synbiotics may intervene through microbiota-gut-brain axis (MGBA). However, their effectiveness safety are still obscure deserve further investigation. purpose this study assess effect probiotics, treating Methods We summarize meta-analyze randomized controlled trials (RCTs) for treatment RCTs comparing with blank control, placebo or conventional be included. plus alone also following electronic databases searched: PubMed, Cochrane Library, EMBASE, CNKI, CBM, VIP, WAN FANG DATA. methodological quality assessed using risk assessment tool. All included analyzed according criteria Handbook. Review Manager 5.3, R-3.5.1 software used publication bias analysis. Grading Recommendations Assessment, Development Evaluation (GRADE) pro-GDT web solution evidence evaluation. Results This review evaluate effects on cognitive function, behavioral psychological symptoms dementia, life (QOL), functional performance activities daily living, compliance intervention Conclusions provide clear dementia.OSF registration number: DOI 10.17605/OSF.IO/2Q3AK.