A toll-like receptor 9 antagonist improves bladder function and white matter sparing in spinal cord injury.
作者： Brian T. David , Sujitha Sampath , Wei Dong , Adee Heiman , Courtney E. Rella
关键词: Anesthesia 、 Urology 、 Spinal cord injury 、 Urinary retention 、 Inflammation 、 Neuropathic pain 、 Urinary bladder 、 White matter 、 TLR9 、 Antagonist 、 Medicine
摘要: Abstract Spinal cord injury (SCI) affects motor, sensory, and autonomic functions. As current therapies do not adequately alleviate functional deficits, the development of new more effective approaches is critical importance. Our earlier investigations indicated that intrathecal administration a toll-like receptor 9 (TLR9) antagonist, cytidine-phosphate-guanosine oligodeoxynucleotide 2088 (CpG ODN 2088), to mice sustaining severe, mid-thoracic contusion diminished neuropathic pain but did alter locomotor deficits. These changes were paralleled by decrease in pro-inflammatory response at epicenter. Using same SCI paradigm treatment regimen, studies investigated effects TLR9 antagonist on bladder function. We report decreases SCI-elicited urinary retention ameliorates morphopathology without affecting kidney A significant improvement white matter sparing was also observed, most likely due...
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