Overview: Physiological Role of K+Channels in the Regulation of Vascular Tone

摘要: Calcium entry through voltage-dependent Ca2+ channels plays an important role in the contractile responses of vascular smooth muscle, particularly resistance vasculature. Thus, agents or interventions that open close these have significant effects on muscle activity. Accordingly, regulation membrane potential changes K+ channel activity, and subsequent alterations activity channels, is a major mechanism vasodilation vasoconstriction, both normal pathophysiological conditions. Activation will result hyperpolarization, closure vasodilation, whereas inhibition opposite effects. Several different types are present most cells. Membrane diameter determined, part, by integrated which regulated multiple dilator constrictor signals muscle. The objective this chapter to provide overview evidence supporting functional roles found