Proton Radiation Therapy for the Treatment of Pediatric Retinoblastoma

摘要: photocoagulation, and thermotherapy. Following plaque radiation therapy, there was a total of 33/255 recurrences (12.9%), with 26/33 occurring within the first year. The median time to recurrence 4.5 months. Sixty-five patients (25.5%) underwent enucleation due poor vision, pain or viable tumor, 44/65 surgeries year 18/65 5 years after treatment. 7 actuarial local rates at 1 year, 10 were 10.2%, 11.8%, 12.2%, respectively, while for 17.3%, 24.3% 24.7%, respectively. Radiation-related complications included cataracts (n Z 64), non-proliferative retinopathy 46), maculopathy 26), retinal neovascularization 25), glaucoma 9), vitreous hemorrhage 2). Conclusions: Plaque therapy is effective management retinoblastoma 88% tumor control years. choice iodine125 provides deeper penetration compared other focal organpreserving therapies, yet limits full ocular systemic exposure, resulting in beneficial control. majority failures occur brachytherapy. ICRB groups B C are bestsuited candidates (basal diameter less than 16 mm thickness equal 9 mm). Author Disclosure: N.R. Patel: None. J. Emrich: N. Ghodasara: F. Troicki: L. Komarnicky-Kocher: C.L. Shields: S. Kaliki: A. Mashayekhi: S.E. Lally: J.A.