Emerging roles of TRPA1 in sensation of oxidative stress and its implications in defense and danger

摘要: Transient receptor potential ankyrin subtype 1 (TRPA1) is a well-known ion channel that play central role for pain sensation. In the peripheral sensory nerve terminals innervating body tegument or organs, TRPA1 detects and activated by diverse harmful environmental internal stimuli. The activation results in neuronal firing, which finally sends warning signal to our brain. However, sensitization sustained of often causes plastic changes both neural pathway tissues, leading pathologic state tissue health mediation. Recently, unique covalent detection mode reactive biological attacks was uncovered mechanisms TRPA1. Notably, pool newly found stimulators includes oxidative stress. Here, we overview nature this interaction, try find meanings participation such rapid ionotrophic component disease exacerbations. Acutely, its relatively response can be understood terms efficiency avoiding milieu as quickly possible, implicated raison d’etre mechanism. Nonetheless, complex situations chronic progress may occur. As well, multiple interplays with known molecules on redox defense mechanism are anticipated. At therapeutic angle, how control promoting body’s defensive will practical question but remains answered. Future investigations likely give more detailed insights understand roles target validity