Formulations and Delivery Limitations of Nucleic-Acid-Based Therapies
作者： Tatiana Segura
DOI: 10.1002/9780470571224.PSE321
关键词: Gene delivery 、 Cell biology 、 Small interfering RNA 、 RNA 、 Targeted drug delivery 、 Molecular biology 、 Cell 、 Oligonucleotide 、 Chemistry 、 Nucleic acid 、 Population
摘要: Gene delivery has expanded to include the of small interfering RNA (siRNA) and oligonucleotides (ON), which can be used decrease or downregulate expression a target protein. An effective gene system protect nucleic acid from degradation, appropriate cell population, efficiently internalized by cell, avoid degradative pathways, ultimately localize nucleus (DNA) cytosol. This article focuses on systemic injection formulations, direct matrix-based delivery, limitations nonviral delivery. Keywords: oligonucleotides; interfering RNA; gene delivery; nonviral acids
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