Hippocampal mammalian target of rapamycin is implicated in stress-coping behavior induced by cannabidiol in the forced swim test.

作者: Ariandra G Sartim , Amanda J Sales , Francisco S Guimarães , Sâmia RL Joca , None

DOI: 10.1177/0269881118784877

关键词: Signal transductionHippocampal formationNeuroscienceBrain-derived neurotrophic factorHippocampusCannabidiolTOR Serine-Threonine KinasesBehavioural despair testBiologyAntidepressant

摘要: Background:Cannabidiol is a non-psychotomimetic compound with antidepressant-like effects. However, the mechanisms and brain regions involved in cannabidiol effects are not yet completely understoo...

参考文章(53)
E. J. Carrier, J. A. Auchampach, C. J. Hillard, Inhibition of an equilibrative nucleoside transporter by cannabidiol: A mechanism of cannabinoid immunosuppression Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 7895- 7900 ,(2006) , 10.1073/PNAS.0511232103
C.B. Filho, C.R. Jesse, F. Donato, R. Giacomeli, L. Del Fabbro, M. da Silva Antunes, M.G. de Gomes, A.T.R. Goes, S.P. Boeira, M. Prigol, L.C. Souza, Chronic unpredictable mild stress decreases BDNF and NGF levels and Na(+),K(+)-ATPase activity in the hippocampus and prefrontal cortex of mice: antidepressant effect of chrysin. Neuroscience. ,vol. 289, pp. 367- 380 ,(2015) , 10.1016/J.NEUROSCIENCE.2014.12.048
Ming Wang, Wei Zhou, Xue Zhou, Fuzhi Zhuang, Qian Chen, Mei Li, Tengfei Ma, Shuling Gu, Antidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice. Behavioural Brain Research. ,vol. 280, pp. 128- 140 ,(2015) , 10.1016/J.BBR.2014.11.039
Attila Tóth, Judit Boczán, Noémi Kedei, Erzsébet Lizanecz, Zsolt Bagi, Zoltán Papp, István Édes, László Csiba, Peter M. Blumberg, Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain Molecular Brain Research. ,vol. 135, pp. 162- 168 ,(2005) , 10.1016/J.MOLBRAINRES.2004.12.003
Nobuyuki Takei, Naoko Inamura, Mihoko Kawamura, Hisaaki Namba, Kenta Hara, Kazuyoshi Yonezawa, Hiroyuki Nawa, Brain-Derived Neurotrophic Factor Induces Mammalian Target of Rapamycin-Dependent Local Activation of Translation Machinery and Protein Synthesis in Neuronal Dendrites The Journal of Neuroscience. ,vol. 24, pp. 9760- 9769 ,(2004) , 10.1523/JNEUROSCI.1427-04.2004
Judith Regina Homberg, Raffaella Molteni, Francesca Calabrese, Marco A Riva, None, The serotonin-BDNF duo: Developmental implications for the vulnerability to psychopathology Neuroscience & Biobehavioral Reviews. ,vol. 43, pp. 35- 47 ,(2014) , 10.1016/J.NEUBIOREV.2014.03.012
D.C. Aguiar, F.A. Moreira, A.L. Terzian, M.V. Fogaça, S.F. Lisboa, C.T. Wotjak, F.S. Guimaraes, Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channels Neuroscience & Biobehavioral Reviews. ,vol. 46, pp. 418- 428 ,(2014) , 10.1016/J.NEUBIOREV.2014.03.026
Ronald S. Duman, Lisa M. Monteggia, A neurotrophic model for stress-related mood disorders. Biological Psychiatry. ,vol. 59, pp. 1116- 1127 ,(2006) , 10.1016/J.BIOPSYCH.2006.02.013
N. Li, B. Lee, R.-J. Liu, M. Banasr, J. M. Dwyer, M. Iwata, X.-Y. Li, G. Aghajanian, R. S. Duman, mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Science. ,vol. 329, pp. 959- 964 ,(2010) , 10.1126/SCIENCE.1190287
E.L. Abel, P.J. Bilitzke, A possible alarm substance in the forced swimming test Physiology & Behavior. ,vol. 48, pp. 233- 239 ,(1990) , 10.1016/0031-9384(90)90306-O