Prevention of urinary tract infection in spinal cord-injured patients: safety and efficacy of a weekly oral cyclic antibiotic (WOCA) programme with a 2 year follow-up—an observational prospective study

摘要: Population: Spinal cord injury (SCI) patients with neurogenic bladder have an increased risk for symptomatic urinary tract infection (UTI). Recurrent UTI requires multiple courses of antibiotic therapy, markedly increasing the incidence multidrug-resistant (MDR) bacteria. Methods: During observational prospective study, we determined safety and efficacy a weekly oral cyclic (WOCA) regimen to prevent in SCI adult undergoing clean intermittent catheterization. The WOCA consisted alternate administration once per week over period at least 2 years. antibiotics chosen were efficient UTI, well tolerated low selection pressure. Results: There was significant decrease antimicrobial consumption linked dramatic UTI. Before intervention, there 9.4 UTIs patient-year, including 197 episodes febrile responsible 45 hospitalizations. Under 1.8 19 No severe adverse events no new cases colonization MDR bacteria reported. Conclusions: In this prospective, pilot study novel approach prevention treatment investigated. Our shows benefit preventing patients.