Oxidative stress biomarkers responses to physical overtraining : Implications for diagnosis

摘要: Overtraining syndrome is characterized by declining performance and transient inflammation following periods of severe training with major health implications for the athletes. Currently, there no single diagnostic marker overtraining. The present investigation examined responses oxidative stress biomarkers to a resistance protocol progressively increased decreased volume/intensity. Twelve males (21.3+/-2.3 years) participated in 12-week consisting five 3-week (T1, 2 tones/week; T2, 8 T3, 14 T4, tones/week), followed period complete rest. Blood/urine samples were collected at baseline 96 h last session each period. Performance (strength, power, jumping ability) after T2 declined thereafter, indicating an overtraining response. (T3) induced sustained leukocytosis, increase urinary isoprostanes (7-fold), TBARS (56%), protein carbonyls (73%), catalase (96%), glutathione peroxidase, oxidized (GSSG) (25%) decline reduced (GSH) (31%), GSH/GSSG total antioxidant capacity. Isoprostanes highly (r=0.764-0.911) correlated drop volume increase. In conclusion, induces marked response which, some cases, was proportional load, suggesting that they may serve as tool diagnosis.