Meloxicam-loaded solvent exchange-induced in situ forming beta-cyclodextrin gel and microparticle for periodontal pocket delivery.

摘要: Abstract The in situ forming system has attracted attention for periodontitis treatment owing to its sustainable drug release localisation at a periodontal pocket. Given low aqueous solubility, beta-cyclodextrin (β-CD) may serve as matrix former of solvent exchange-induced gel (ISG) and microparticle (ISM). Meloxicam (Mex)-loaded-β-CD ISG ISM were prepared using β-CD dimethyl sulphoxide the internal phase camellia oil comprising 5% glyceryl monostearate external Mex-loaded systems 40% easily injected via 24-gauge needle. During exchange with phosphate buffer saline (pH 6.8), highly concentrated promoted inversion aggregates into matrix-like. Upon exposure phase, transformed microparticles extended 7 days minimised initial burst following Fickian diffusion. Moreover, potential degradability was evident from high weight loss. High maximum deformation force viscous character initiated slow diffusion rate system. Therefore, is local Mex-controlled anti-inflammatory treatment.