NADPH oxidases as therapeutic targets in ischemic stroke

摘要: Reactive oxygen species (ROS) act physiologically as signaling molecules. In pathological conditions, such ischemic stroke, ROS are released in excessive amounts and upon reperfusion exceed the body’s antioxidant detoxifying capacity. This process leads to brain tissue damage during reoxygenation. Consequently, strategies have long been suggested a therapy for experimental but clinical trials not yet able promote translation of this concept into patient treatment regimens. As an evolution concept, recent studies targeted sources generation—rather than themselves. context, NADPH oxidases identified important generators cerebral vasculature under both physiological conditions general ischemia/reoxygenation particular. Inhibition or genetic deletion certain oxidase isoforms has found considerably reduce injury stroke. review focuses on advances understanding oxidase-mediated vasculature, particularly at level blood–brain barrier, highlights promising inhibitory that target oxidases.