Composition of Alkyl Ether-Linked Phospholipids in Mammalian Tissues

摘要: In 1979, the structure of a lipid chemical mediator hypersensitivity, platelet-activating factor (PAF) (Benveniste et al., 1972), was proposed to be that an alkyl ether-containing phospholipid, l-O-alkyl-2-acetyl-sn-glycero-3-phosphocho-line 1979; Demopoulos 1979). Final elucidation PAF from IgE-sensitized rabbit basophils performed in 1980 (Hanahan 1980). The presence ether moiety at sn-1 position glycerol backbone found critically important. At same time, this unique phospholipid reported cause dramatic hypotension one-kidney, one-clip hypertensive rat (Blank Thus, first description by three independent groups. Moreover, recent precise studies many investigators revealed exhibits, fact, variety potent biological activities other than and hypotensive Arnoux, 1983; Benveniste Vargaftig, Lee Snyder, 1984). For instance, low concentration activates or causes aggregation leukocytes such as neutrophils, macrophages, monocytes. also shown increase vascular permeability bronchoconstriction, smooth muscle contraction, constriction coronary artery isolated guinea pig heart, glycogenosis perfused liver. Very recently, induce secretion amylase pancreas (Soling above observations strongly suggest acts autacoid hormonelike substance vivo, particularly inflammatory reactions. target tissues cells seem widely spread mammalian body.