Methodological, biological and clinical aspects of circulating free DNA in metastatic colorectal cancer
作者： Karen-Lise G. Spindler
DOI: 10.1080/0284186X.2016.1253861
关键词: Peripheral blood 、 Circulating DNA 、 Immunology 、 Colorectal cancer 、 Internal medicine 、 Oncology 、 Genetic Alteration 、 Medicine 、 Colorectal Tumors 、 Circulating free DNA 、 Palliative Therapy
摘要: AbstractBackground: Circulating DNA can be used to measure the total cell-free (cfDNA) and for detection quantification of tumor-specific genetic alterations in peripheral blood, broad clinical potential circulating has attracted increasing focus over past decade. Concentrations are high metastatic colorectal cancer (CRC), levels cfDNA have been reported hold strong prognostic value. Colorectal tumors characterized by a frequency well known, clinically relevant alteration, which is readily detected holds tailoring palliative therapy monitoring during treatment. This review aims present current literature specifically data on utility mutations (mCRC).Method: Methodological, biological aspects discussed based most recent development this specific ...
sci-hub.se 参考文章(95)
Philippe Anker, Hugh Mulcahy, Xu Qi Chen, Maurice Stroun, Detection of circulating tumour DNA in the blood (plasma/serum) of cancer patients. Cancer and Metastasis Reviews. ,vol. 18, pp. 65- 73 ,(1999) , 10.1023/A:1006260319913
Eleonora Zonta, Philippe Nizard, Valérie Taly, None, Assessment of DNA Integrity, Applications for Cancer Research Advances in Clinical Chemistry. ,vol. 70, pp. 197- 246 ,(2015) , 10.1016/BS.ACC.2015.03.002
M Stroun, J Lyautey, C Lederrey, A Olson-Sand, P Anker, About the possible origin and mechanism of circulating DNA apoptosis and active DNA release. Clinica Chimica Acta. ,vol. 313, pp. 139- 142 ,(2001) , 10.1016/S0009-8981(01)00665-9
Abel Jacobus Bronkhorst, Janine Aucamp, Piet J. Pretorius, Cell-free DNA: Preanalytical variables Clinica Chimica Acta. ,vol. 450, pp. 243- 253 ,(2015) , 10.1016/J.CCA.2015.08.028
Circulating tumor DNA to monitor metastatic breast cancer. The New England Journal of Medicine. ,vol. 369, pp. 93- 94 ,(2013) , 10.1056/NEJMC1306040
Aung Naing, Gerald S. Falchook, David S. Hong, Veronica R. Holley, Goran Cabrilo, Jennifer J. Wheler, Sarina A. Piha-Paul, Ralph G. Zinner, Agop Y. Bedikian, Michael J. Overman, Bryan K. Kee, Kevin B. Kim, E. Scott Kopetz, Rajyalakshmi Luthra, Frank Diehl, Funda Meric-Bernstam, Razelle Kurzrock, Filip Janku, Philipp Angenendt, Apostolia M. Tsimberidou, Siqing Fu, Actionable mutations in plasma cell-free DNA in patients with advanced cancers referred for experimental targeted therapies Oncotarget. ,vol. 6, pp. 12809- 12821 ,(2015) , 10.18632/ONCOTARGET.3373
Karen-Lise Garm Spindler, Niels Pallisgaard, Ane Lindegaard Appelt, Rikke Fredslund Andersen, Jakob V. Schou, Dorte Nielsen, Per Pfeiffer, Mette Yilmaz, Julia S. Johansen, Estrid V. Hoegdall, Anders Jakobsen, Benny V. Jensen, Clinical utility of KRAS status in circulating plasma DNA compared to archival tumour tissue from patients with metastatic colorectal cancer treated with anti-epidermal growth factor receptor therapy. European Journal of Cancer. ,vol. 51, pp. 2678- 2685 ,(2015) , 10.1016/J.EJCA.2015.06.118
John Ploen, Karen-Lise G Spindler, Rikke F Andersen, Anders Jakobsen, Niels Pallisgaard, Gemcitabine and capecitabine for heavily pre-treated metastatic colorectal cancer patients--a phase II and translational research study. Anticancer Research. ,vol. 34, pp. 845- 850 ,(2014)
S A Leon, B Shapiro, M J Yaros, D M Sklaroff, Free DNA in the Serum of Cancer Patients and the Effect of Therapy Cancer Research. ,vol. 37, pp. 646- 650 ,(1977)
Jean Sebastien Frenel, Suzanne Carreira, Jane Goodall, Desam Roda, Raquel Perez-Lopez, Nina Tunariu, Ruth Riisnaes, Susana Miranda, Ines Figueiredo, Daniel Nava-Rodrigues, Alan Smith, Christophe Leux, Isaac Garcia-Murillas, Roberta Ferraldeschi, David Lorente, Joaquin Mateo, Michael Ong, Timothy A. Yap, Udai Banerji, Delila Gasi Tandefelt, Nick Turner, Gerhardt Attard, Johann S. de Bono, Serial Next-Generation Sequencing of Circulating Cell-Free DNA Evaluating Tumor Clone Response To Molecularly Targeted Drug Administration. Clinical Cancer Research. ,vol. 21, pp. 4586- 4596 ,(2015) , 10.1158/1078-0432.CCR-15-0584