Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy

摘要: Even though conventional chemotherapeutic management of cancer has reduced morbidity and mortality to a great extent, virtually all agents cause damage healthy cells, necessitating exploration novel anticancer that exert their effects through an alternate mode action. Objectives our research were twofold. First, we explored the promising potential histone deacetylase inhibitor sulforaphane for epigenetic therapy as this therapeutic approach aims reverse aberrant modifications affect gene expression. In vitro cell culture studies performed using B16 S91 melanoma cells showed inhibited growth proliferation by downregulating deacetylation enzymes. The second part investigated polymeric drug delivery systems increase efficacy minimize side R,S-sulforaphane. Albumin microspheres encapsulating developed spray drying. Microspheres characterized morphology, size zeta potential. Cell in vivo tumor-bearing C57BL/6 mice demonstrated albumin based system was efficacious enhance effect activity sulforaphane.