Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies
作者： K. Selesniemi , H.-J. Lee , A. Muhlhauser , J. L. Tilly
关键词: Receptor 、 Miscarriage 、 Andrology 、 Aneuploidy 、 Meiosis 、 Regulator 、 Infertility 、 Genetics 、 Oocyte 、 Germline 、 Biology
摘要: Increased meiotic spindle abnormalities and aneuploidy in oocytes of women advanced maternal ages lead to elevated rates infertility, miscarriage, trisomic conceptions. Despite the significance problem, strategies sustain oocyte quality with age have remained elusive. Here we report that adult female mice maintained under 40% caloric restriction (CR) did not exhibit aging-related increases aneuploidy, chromosomal misalignment on metaphase plate, abnormalities, or mitochondrial dysfunction (aggregation, impaired ATP production), all which occurred age-matched ad libitum-fed controls. The effects CR aging females were reproduced by deletion metabolic regulator, peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α). Thus, during adulthood loss PGC-1α function maintains germline stability its proper segregation meiosis, such ovulated aged previously lacking are comparable those young prime reproductive life.
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