Prenatal DDT and DDE exposure and child IQ in the CHAMACOS cohort.

摘要: Although banned in most countries, dichlorodiphenyl-trichloroethane (DDT) continues to be used for vector control some malaria endemic areas. Previous findings from the Center Health Assessment of Mothers and Children Salinas (CHAMACOS) cohort study found increased prenatal levels DDT its breakdown product dichlorodiphenyl-dichloroethylene (DDE) associated with altered neurodevelopment children at 1 2years age. In this study, we combined measured maternal DDT/E concentrations during pregnancy obtained prospective birth predicted DDE estimated a retrospective cohort. Using generalized estimating equation (GEE) linear regression models, evaluated relationship serum children's cognition ages 7 10.5years as assessed using Full Scale Intelligence Quotient (IQ) 4 subtest scores (Working Memory, Perceptual Reasoning, Verbal Comprehension, Processing Speed) Wechsler (WISC). GEE analyses incorporating both age 10.5 (n=619), were not IQ or any WISC subscales (p-value>0.05). assessing each time point separately, inversely Speed 7years (n=316), but (n=595). We evidence effect modification by sex. girls, boys, 7years. conclude that may delayed between cognitive development modified sex, girls being more adversely affected.