The human hippocampus at 7 T--in vivo MRI.

摘要: The human hippocampus plays a central role in various neuropsychiatric disorders, such as temporal lobe epilepsy (TLE), Alzheimer's dementia, mild cognitive impairment, and schizophrenia. Its volume, morphology, inner structure, function are of scientific clinical interest. Magnetic resonance (MR) imaging is widely employed tool neuroradiological workup regarding changes brain anatomy, (sub-) volumes, cerebral including the hippocampus. Gain intrinsic MR signal provided by higher field strength scanners concomitant improvements spatial resolution seem highly valuable. An examination protocol permitting complete, high-resolution at 7 T was implemented. Coronal proton density, T2, T2*, fluid-attenuated inversion recovery contrasts were acquired well an isotropic 3D magnetization-prepared rapid acquisition gradient-echo (500 microm voxel dimension, noninterpolated). Observance energy deposition restrictions within acceptable scan times remained challenging thin, spin-echo-based sections. At enabled T, demarcation some internal features gray/white matter differentiation depiction hippocampal mantle becomes much more viable when compared with 1.5 T; thus, future, this technology might help diagnosis subtle changes.