Bismuth increases hydroxyl radical-scavenging activity of histamine H2-receptor antagonists.
作者： Margarita Kirkova , Albena Alexandrova , Neli Yordanova
DOI:
关键词: Receptor 、 Ascorbic acid 、 Stereochemistry 、 Hydroxyl radical 、 Cimetidine 、 Ranitidine 、 Bismuth 、 Deoxyribose 、 Histamine H2 receptor 、 Chemistry 、 Medicinal chemistry
摘要: The effects of histamine H 2 -receptor antagonists, alone or in a combination with bismuth, on *OH-provoked degradation deoxyribose were studied. antagonists (cimetidine, ranitidine and roxatidine), themselves decreased the damage Fenton-type systems. In combinations their inhibitory effect Fenton system (Fe(III)/ascorbic acid + O ) was stronger. Moreover, unlike Fe(III) Cu(IT), which presence ascorbic led to an increase *OH formation (deoxyribose damage), Bi(III) showed opposite effect. present results are interpreted view better scavenging activity bismuth complexes as compared that corresponding drugs. These findings might be one more explanation why salts, acid-reducing agents, effective anti-ulcer agents.
参考文章(43)
Barry Halliwell, Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Its role in degradation of hyaluronic acid by a superoxide-generating system. FEBS Letters. ,vol. 96, pp. 238- 242 ,(1978) , 10.1016/0014-5793(78)80409-8
K Berstad, I Wilhelmsen, O Hundal, A Berstad, M Bergseth, S Olafsson, S Tefera, Bismuth therapy for Helicobacter pylori infection. A review of five years experience at a university hospital in Norway. Journal of Physiology and Pharmacology. ,vol. 47, pp. 31- 49 ,(1996)
J. A. Cesolari, P. San Miguel, O. A. Bedini, O. M. Laudanno, Evidence of anti-oxidant role of sucralfate in gastric mucosal protection. The Italian journal of gastroenterology. ,vol. 22, pp. 19- 21 ,(1990)
Barry Halliwell, John M.C. Gutteridge, Formation of a thiobarbituric-acid-reactive substance from deoxyribose in the presence of iron salts FEBS Letters. ,vol. 128, pp. 347- 352 ,(1981) , 10.1016/0014-5793(81)80114-7
John M.C. Gutteridge, Stephanie Wilkins, Copper salt-dependent hydroxyl radical formation. Damage to proteins acting as antioxidants. Biochimica et Biophysica Acta. ,vol. 759, pp. 38- 41 ,(1983) , 10.1016/0304-4165(83)90186-1
E Graf, J R Mahoney, R G Bryant, J W Eaton, Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site. Journal of Biological Chemistry. ,vol. 259, pp. 3620- 3624 ,(1984) , 10.1016/S0021-9258(17)43139-5
Barry Halliwell, Martin Grootveld, John M. C. Gutteridge, Methods for the Measurement of Hydroxyl Radicals in Biochemical Systems: Deoxyribose Degradation and Aromatic Hydroxylation Methods of Biochemical Analysis. ,vol. 33, pp. 59- 90 ,(2006) , 10.1002/9780470110546.CH2
Mohamed. Masarwa, Haim. Cohen, Dan. Meyerstein, David L. Hickman, Andreja. Bakac, James H. Espenson, Reactions of low-valent transition-metal complexes with hydrogen peroxide. Are they "Fenton-like" or not? 1. The case of Cu+aq and Cr2+aq Journal of the American Chemical Society. ,vol. 110, pp. 4293- 4297 ,(1988) , 10.1021/JA00221A031
John M.C. Gutteridge, Stephanie Wilkins, Copper-dependent hydroxyl radical damage to ascorbic acid: Formation of a thiobarbituric acid-reactive product FEBS Letters. ,vol. 137, pp. 327- 330 ,(1982) , 10.1016/0014-5793(82)80377-3
J M C Gutteridge, Ferrous-salt-promoted damage to deoxyribose and benzoate. The increased effectiveness of hydroxyl-radical scavengers in the presence of EDTA. Biochemical Journal. ,vol. 243, pp. 709- 714 ,(1987) , 10.1042/BJ2430709