Analysis of neoplasms induced by Cas-Br-M MuLV tumor extracts.

摘要: Cas-Br-M is an ecotropic murine leukemia virus isolated from wild mice that induces a wide spectrum of hematopoietic neoplasms, including T and B cell lymphomas, myelogenous leukemias, erythroleukemias. The purpose this study was to determine if the induction neoplasms belonging multiple lineages due itself or generation lineage-specific recombinant viruses. results demonstrate in some instances (two 12 tumor extracts tested), viruses can be recovered primary Cas-Br-M-induced tumors will induce lymphomas single inoculated as newborns. One these mink focus-forming other replication-defective, fibroblast-transforming early lineage mice. Histologic flow microfluorometric surface antigen analyses vitro adapted are presented support modified scheme development.