A Historical Perspective on the Use of Radionuclides for Therapy

摘要: At present, standard of care for targeted therapy with radionuclides include; 131I well-differentiated thyroid cancer; 89Sr chloride, and 153Sm-EDTMP bone pain; radionuclide microembolization either resin or glass microspheres; radiolabeled antibodies in lymphoma; metaiodobenzylguanidine pheochromocytoma; radio peptide carcinoid, other endocrine tumors. Growth this sector nuclear medicine has been modest. Recent advances radiotherapy are predicted to set the stage a phase rapid growth therapeutic aspects medicine, as most unique potentially distinctive utilitarian feature our specialty. A plethora targeting agents, ranging from small molecules large nanoparticles offers many alternatives pharmaceutical carrier radioactivity. In particular, major improvement efficient production range biologicals such peptides, nanobodies, affibodies, occurred recent past led serious consideration these agents carriers radioactivity after parenteral injection. brief overview, we highlight selected that have quantitative imaging, cancer biology, radiobiology/radiochemistry which likely significant short-term impact on therapy. regard imaging improvements, there is now widespread availability potential truly images, especially fusion images based PET-CT, PET MRI, SPECT-CT ability permit internal dosimetry guide optimize dosing better management individual patients. Such leading opportunities use theranostic radiotracers, whereby same drug minor changes used both diagnosis at tracer levels tumoricidal levels. From biology point view, specific oncoproteins can restore some cells more, nearly normal differentiated state may special relevance cancers (Pacak et al. 2012). Thus, non-iodine avid be concentrate radioactive iodine MIBG, by treatment short course drugs overcome effects oncogenic proteins. practical methods accessing alpha emitters developed.