Alterations in circulating amino acid metabolite ratio associated with arginase activity are potential indicators of metabolic syndrome: The Korean genome and epidemiology study

摘要: Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs production and has been implicated in various metabolic disorders. This study examined whether circulating amino acid metabolite ratios are associated NOS activities arginine bioavailability is syndrome (MetS). Data related to were collected from non-diabetic Koreans without cardiovascular disease (n = 1998) the Ansan–Ansung cohorts (2005–2006). Subsequently, correlation multivariate logistic regression analyses performed. With increase number of MetS risk factors, metabolites, such as those ornithine/citrulline, proline/citrulline, ornithine/arginine, also significantly increased, whereas decreased. These correlated risk-related parameters, remained significant after adjusting for covariates. In addition, analysis revealed that high metabolites low bioavailability, indicated increased a risk. demonstrated altered indicates activity decreased both can be potential markers