Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice.
作者： EC Gavioli , CW Vaughan , G Marzola , Remo Guerrini , VA Mitchell
DOI: 10.1007/S00210-004-0939-0
关键词: Tail suspension test 、 NOP 、 Receptor antagonist 、 Endocrinology 、 Chemistry 、 Blockade 、 Antagonist 、 Receptor 、 Behavioural despair test 、 Nociceptin receptor 、 Internal medicine
摘要: Receptor antagonist and knockout studies have demonstrated that blockade of signalling via nociceptin/orphanin FQ (N/OFQ) its receptor (NOP) has antidepressant-like effects in mice submitted to the forced swimming test (FST). The aim present study was explore further properties NOP UFP-101 different species (mouse rat) using assays [FST tail suspension (TST)], investigate mechanism(s) involved actions.
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