Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack.

摘要: Emotional stress triggers takotsubo cardiomyopathy in postmenopausal women. Clinical analysis of autonomic nervous function has revealed a transient increase sympathetic activity and decrease vagal activity. Immobilization (IMO) rats can reproduce the electrocardiographic left ventriculographic changes that occur cardiomyopathy, both which are prevented by combined blockade alpha- beta-adrenoceptors. Estrogen supplementation partially attenuated these cardiac changes. It also IMO-induced c-Fos immunoreactivity, or c-fos mRNA expression lateral septum, medial amygdaloid nucleus, paraventricular hypothalamic dorsomedial laterodorsal tegmental locus ceruleus; regions contain central neurons with immunoreactive estrogen receptors. downregulated adrenal gland heart, suggesting an stress-induced hypothalamo-sympathoadrenal outflow from system to target organs. treatment upregulated levels cardioprotective substances, such as atrial natriuretic peptide heat shock protein 70, heart. These data suggest reduction following menopause might be involved primary cause indirect action on direct