A Specific Gut Microbiota Dysbiosis of Type 2 Diabetic Mice Induces GLP-1 Resistance through an Enteric NO-Dependent and Gut-Brain Axis Mechanism
作者： Estelle Grasset , Anthony Puel , Julie Charpentier , Xavier Collet , Jeffrey E. Christensen
DOI: 10.1016/J.CMET.2017.06.003
关键词: Endocrinology 、 Internal medicine 、 Gut–brain axis 、 Dysbiosis 、 Gut flora 、 Receptor 、 Enteric nervous system 、 Gastric emptying 、 Biology 、 Nitric oxide 、 Diabetes mellitus
摘要: Summary Glucagon-like peptide-1 (GLP-1)-based therapies control glycemia in type 2 diabetic (T2D) patients. However, in some patients the treatment must be discontinued, defining a state of GLP-1 resistance. In animal models we identified a specific set of ileum bacteria impairing the GLP-1-activated gut-brain axis for the control of insulin secretion and gastric emptying. Using prediction algorithms, we identified bacterial pathways related to amino acid metabolism and transport system modules associated to GLP-1 resistance. The …
elsevier.com
sci-hub.se 参考文章(80)
Panagiotis S. Kabouridis, Reena Lasrado, Sarah McCallum, Song Hui Chng, Hugo J. Snippert, Hans Clevers, Sven Pettersson, Vassilis Pachnis, Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria Neuron. ,vol. 85, pp. 289- 295 ,(2015) , 10.1016/J.NEURON.2014.12.037
R. E. Ley, F. Backhed, P. Turnbaugh, C. A. Lozupone, R. D. Knight, J. I. Gordon, Obesity Alters Gut Microbial Ecology Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 11070- 11075 ,(2005) , 10.1073/PNAS.0504978102
M. Ozbek, M. Erdogan, M. Karadeniz, S. Cetinkalp, A. G. Ozgen, F. Saygili, C. Yilmaz, M. Tuzun, Evaluation of beta cell dysfunction by mixed meal tolerance test and oral L-arginine in patients with newly diagnosed type 2 diabetes mellitus. Experimental and Clinical Endocrinology & Diabetes. ,vol. 117, pp. 573- 576 ,(2009) , 10.1055/S-0029-1234087
Emeran A Mayer, Kirsten Tillisch, Arpana Gupta, None, Gut/brain axis and the microbiota Journal of Clinical Investigation. ,vol. 125, pp. 926- 938 ,(2015) , 10.1172/JCI76304
Christian Widmann, Wanda Dolci, Bernard Thorens, Internalization and Homologous Desensitization of the GLP-1 Receptor Depend on Phosphorylation of the Receptor Carboxyl Tail at the Same Three Sites Molecular Endocrinology. ,vol. 11, pp. 1094- 1102 ,(1997) , 10.1210/MEND.11.8.9959
Stéphane Dalle, Rémy Burcelin, Pierre Gourdy, Specific actions of GLP-1 receptor agonists and DPP4 inhibitors for the treatment of pancreatic β-cell impairments in type 2 diabetes. Cellular Signalling. ,vol. 25, pp. 570- 579 ,(2013) , 10.1016/J.CELLSIG.2012.11.009
Mauro Tiso, Alan N. Schechter, Nitrate Reduction to Nitrite, Nitric Oxide and Ammonia by Gut Bacteria under Physiological Conditions PLOS ONE. ,vol. 10, pp. e0119712- ,(2015) , 10.1371/JOURNAL.PONE.0119712
D. J. Drucker, J. Philippe, S. Mojsov, W. L. Chick, J. F. Habener, Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line Proceedings of the National Academy of Sciences of the United States of America. ,vol. 84, pp. 3434- 3438 ,(1987) , 10.1073/PNAS.84.10.3434
Masakazu Ishii, Rei Shibata, Kazuhisa Kondo, Takahiro Kambara, Yuuki Shimizu, Tohru Tanigawa, Yasuko K. Bando, Masahiro Nishimura, Noriyuki Ouchi, Toyoaki Murohara, Vildagliptin Stimulates Endothelial Cell Network Formation and Ischemia-induced Revascularization via an Endothelial Nitric-oxide Synthase-dependent Mechanism Journal of Biological Chemistry. ,vol. 289, pp. 27235- 27245 ,(2014) , 10.1074/JBC.M114.557835
Hana Kozakova, Martin Schwarzer, Ludmila Tuckova, Dagmar Srutkova, Elzbieta Czarnowska, Ilona Rosiak, Tomas Hudcovic, Irma Schabussova, Petra Hermanova, Zuzana Zakostelska, Tamara Aleksandrzak-Piekarczyk, Anna Koryszewska-Baginska, Helena Tlaskalova-Hogenova, Bozena Cukrowska, Colonization of germ-free mice with a mixture of three lactobacillus strains enhances the integrity of gut mucosa and ameliorates allergic sensitization. Cellular & Molecular Immunology. ,vol. 13, pp. 251- 262 ,(2016) , 10.1038/CMI.2015.09