Lipoprotein lipase: recent contributions from molecular biology.

摘要: Lipoprotein lipase (LPL) is a glycoprotein enzyme that produced in several cells and tissues. LPL belongs to large gene family includes, among others, hepatic pancreatic lipase. After secretion, becomes anchored on the luminal surface of capillary endothelial cells. There it hydrolyzes triglycerides triglyceride-rich lipoproteins, generating free fatty acids can serve either as direct energy source or be stored. Through this action plays pivotal role both lipoprotein metabolism. production regulated tissue-specific fashion by developmental, hormonal, nutritional factors. The recent availability regulatory sequences will greatly facilitate these studies future. In man, mutations resulting familial deficiency have been delineated at molecular level. study not only very beneficial from clinical point view but also contributes major way our understanding structure-function relationship other lipases. review attention given relating regulation production, defects underlying deficiency,