Specificity and function of monoclonal antibodies directed against Ewing sarcoma cells.
作者： Liang Ru Shi , Dirk Eichelbauer , Franz Borchard , Herbert J�rgens , Ulrich G�bel
DOI: 10.1007/BF01525643
关键词: Biology 、 Cancer research 、 Antigen 、 Monoclonal antibody 、 Pathology 、 Cell culture 、 Sarcoma 、 Immunohistochemistry 、 Antibody 、 Bone marrow 、 Ewing's sarcoma
摘要: A selection of 16 monoclonal antibodies has been produced against a fresh Ewing's sarcoma (ES) tumor mixed with permanent ES cell line. The majority identify an 80-kDa molecule, which is not detected on healthy tissues except certain cultured monocytes. One antibody recognize the CD2 ligand MIC2 and 2 (numbers 13 16) define higher-molecular-mass antigen. Antibody also expressed mesenchymal fibroblasts bone marrow or fetal origin. Tumorspecific antigen expression potentially linked to chromosome 22 abnormality decribed in sarcoma.
springer.com
sci-hub.se 参考文章(15)
G Lenoir, M P Berger, C Turc-Carel, T Philip, I Philip, [Chromosomal translocation (11; 22) in cell lines of Ewing's sarcoma]. Comptes rendus des seances de l'Academie des sciences. Serie III, Sciences de la vie. ,vol. 296, pp. 1101- 1103 ,(1983)
Ludvik R. Donner, Cytogenetics and molecular biology of small round-cell tumors and related neoplasms. Current status. Cancer Genetics and Cytogenetics. ,vol. 54, pp. 1- 10 ,(1991) , 10.1016/0165-4608(91)90023-N
Pilar Garin-Chesa, Joseph M. Lane, Erich J. Fellinger, Wolfgang J. Rettig, Sai L. Su, Paula DeAngelis, Biochemical and Genetic Characterization of the HBA71 Ewing's Sarcoma Cell Surface Antigen Cancer Research. ,vol. 51, pp. 336- 340 ,(1991)
C. Gelin, F. Aubrit, A. Phalipon, B. Raynal, S. Cole, M. Kaczorek, A. Bernard, The E2 Antigen, a 32 Kd Glycoprotein Involved in T-cell Adhesion Processes, Is the MIC2 Gene Product The EMBO Journal. ,vol. 8, pp. 3253- 3259 ,(1989) , 10.1002/J.1460-2075.1989.TB08485.X
T J Brown, H Marquardt, M N Lioubin, Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells. Journal of Immunology. ,vol. 139, pp. 2977- 2983 ,(1987)
S Hara, E Ishii, S Tanaka, J Yokoyama, K Katsumata, J Fujimoto, J Hata, A monoclonal antibody specifically reactive with Ewing's sarcoma. British Journal of Cancer. ,vol. 60, pp. 875- 879 ,(1989) , 10.1038/BJC.1989.383
Eduardo Rodriguez, Chandrika Sreekantaiah, William Gerald, Victor E. Reuter, Robert J. Motzer, R.S.K. Chaganti, A recurring translocation, t(11;22)(p13;q11.2), characterizes intra-abdominal desmoplastic small round-cell tumors Cancer Genetics and Cytogenetics. ,vol. 69, pp. 17- 21 ,(1993) , 10.1016/0165-4608(93)90105-U
J. Whang-Peng, T.J. Triche, T. Knutsen, J. Miser, S. Kao-Shan, S. Tsai, M.A. Israel, Cytogenetic characterization of selected small round cell tumors of childhood Cancer Genetics and Cytogenetics. ,vol. 21, pp. 185- 208 ,(1986) , 10.1016/0165-4608(86)90001-4
Jessica Zucman, Olivier Delattre, Chantal Desmaze, Béatrice Plougastel, Isabelle Joubert, Thomas Melot, Martine Peter, Pieter De Jong, Guy Rouleau, Alain Aurias, Gilles Thomas, Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. Genes, Chromosomes and Cancer. ,vol. 5, pp. 271- 277 ,(1992) , 10.1002/GCC.2870050402
G. Hamilton, R. Mallinger, M. Havel, Ewing's-sarcoma-associated HBA-71 tumor antigen represents a new differentiation marker of human thymocytes. Journal of Cancer Research and Clinical Oncology. ,vol. 115, pp. 592- 596 ,(1989) , 10.1007/BF00391364