A cross-sectional study: serum CCL3/MIP-1α levels may reflect lumbar intervertebral disk degeneration in Han Chinese people.

摘要: Background The macrophage inflammatory protein-1α (MIP-1α), also named chemokine cytokine ligand 3 (CCL3), has been detected in nucleus pulposus and increased following stimulation. Objective current study was performed to explore the relationship between serum CCL3/MIP-1α levels with lumbar intervertebral disk degeneration (IDD). Patients methods A total of 132 patients confirmed by magnetic resonance imaging 126 healthy controls were enrolled study. Radiological evaluation IDD conducted using a 3.0-T scanner for entire vertebra region. Degeneration assessed Schneiderman criteria. Serum investigated sandwich enzyme-linked immunosorbent assay. Visual Analog Scale scores Oswestry Disability Index index recorded clinical severity. Results Elevated concentrations CCL3 found compared asymptomatic volunteers. case group included 49 grade 1, 42 2, 41 3. Grade 2 had significantly higher those 1. positively related degree degeneration. In addition, demonstrated significant correlation severity determined index. Conclusion may serve as biomarker IDD.