Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions

摘要: Glioblastoma multiforme (GBM) causes significant neurological morbidity and short survival times. Brain invasion by GBM is associated with poor prognosis. Recent clinical trials of bevacizumab in newly-diagnosed found no beneficial effects on overall times; however, the baseline health-related quality life performance status were maintained longer group glucocorticoid requirement was lower. Here, we construct a clinical-scale model whose predictions uncover new pattern recurrence 11/70 bevacizumab-treated patients. The findings support an exception to Folkman hypothesis: grows absence angiogenesis cycle proliferation brain that expands necrosis. Furthermore, necrosis positively correlated 26 GBM. unintuitive results explain unusual suggest hypotheses dynamic migration active transport, mechanism hypoxia-driven invasion.