Reducing Presystemic Drug Metabolism

Barbara Haeberlin, Werner Rubas, Harold W. Nolen III, David R. Friend, In vitro evaluation of dexamethasone-β-D-glucuronide for colon-specific drug delivery Pharmaceutical Research. ,vol. 10, pp. 1553- 1562 ,(1993) , 10.1023/A:1018956232628

Josias H Hamman, Gill M Enslin, Awie F Kotz??, Oral delivery of peptide drugs: barriers and developments. BioDrugs. ,vol. 19, pp. 165- 177 ,(2005) , 10.2165/00063030-200519030-00003

Hans Bundgaard, Gitte Juel Rasmussen, Prodrugs of peptides. 9. Bioreversible N-alpha-hydroxyalkylation of the peptide bond to effect protection against carboxypeptidase or other proteolytic enzymes. Pharmaceutical Research. ,vol. 8, pp. 313- 322 ,(1991) , 10.1023/A:1015833229554

Munir A. Hussain, Bruce J. Aungst, Eli Shefter, Prodrugs for Improved Oral β-Estradiol Bioavailability Pharmaceutical Research. ,vol. 5, pp. 44- 47 ,(1988) , 10.1023/A:1015863412137

Mei-Juan Zou, Colon-specific drug delivery systems based on cyclodextrin prodrugs:In vivoevaluation of 5-aminosalicylic acid from its cyclodextrin conjugates World Journal of Gastroenterology. ,vol. 11, pp. 7457- 7460 ,(2005) , 10.3748/WJG.V11.I47.7457

Harold W. Nolen III, David R. Friend, Menthol-β-D-Glucuronide: A Potential Prodrug for Treatment of the Irritable Bowel Syndrome Pharmaceutical Research. ,vol. 11, pp. 1707- 1711 ,(1994) , 10.1023/A:1018950930134

A.William Tank, Henry Weiner, Jane A. Thurman, Enzymology and subcellular localization of aldehyde oxidation in rat liver: Oxidation of 3,4-dihydroxyphenylacetaldehyde derived from dopamine to 3,4-dihydroxyphenylacetic acid Biochemical Pharmacology. ,vol. 30, pp. 3265- 3275 ,(1981) , 10.1016/0006-2952(81)90598-0

H. -J. Horst, W. J. H�ltje, M. Dennis, A. Coert, J. Geelen, K. D. Voigt, Lymphatic absorption and metabolism of orally administered testosterone undecanoate in man. Journal of Molecular Medicine. ,vol. 54, pp. 875- 879 ,(1976) , 10.1007/BF01483589

Thomas N. Tozer, Jean Rigod, Andrew D. McLeod, Ramon Gungon, M. Kim Hoag, David R. Friend, Colon-specific delivery of dexamethasone from a glucoside prodrug in the guinea pig. Pharmaceutical Research. ,vol. 8, pp. 445- 454 ,(1991) , 10.1023/A:1015838825437

TORSTEN EHRIG, WILLIAM F. BOSRON, TING-KAI LI, Alcohol and aldehyde dehydrogenase. Alcohol and Alcoholism. ,vol. 25, pp. 105- 116 ,(1990) , 10.1093/OXFORDJOURNALS.ALCALC.A044985