Differentiation of human adipose stromal cells into hepatic lineage in vitro and in vivo
作者： Min Jeong Seo , Su Young Suh , Yong Chan Bae , Jin Sup Jung
DOI: 10.1016/J.BBRC.2004.12.158
关键词: Stem cell 、 Stem cell transplantation for articular cartilage repair 、 Hepatocyte growth factor 、 Mesenchymal stem cell 、 Stromal cell 、 Cell biology 、 Adipose tissue 、 Biology 、 Adult stem cell 、 Immunology 、 Embryonic stem cell
摘要: Embryonic stem cells (ES cells), bone marrow-derived mesenchymal cells, umbilical cord blood-derived and hepatic in liver have been known as a useful source that can induce to differentiate into hepatocytes. In this study, we examined whether human adipose tissue-derived stromal (hADSC) lineage vitro. hADSC, were induced hepatocyte-like by the treatment of HGF OSM, had morphology similar Addition DMSO enhanced differentiation RT-PCR immunocytochemical analysis showed hADSC express albumin alpha-fetoprotein during differentiation. Differentiated LDL uptake production urea. Additionally, transplanted CCl4-injured SCID mouse model able be differentiated hepatocytes they expressed vivo. Mesenchymal isolated from tissue are immunocompatible easily isolated. Therefore, may become an alternative hepatocyte regeneration or cell transplantation.
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