DRUG RESISTANCE IN CANCER CHEMOTHERAPY- AN OVERVIEW -

摘要: Drug resistance is one of the primary obstacles in cancer chemotherapy. The causes drug resistances are varied. attributed to genomic instability while alteration membrane permeability and inability reach target sites, inactivation by enzymes, mutation altered expression proteins there affecting interactions some mechanism acquired resistance. In addition genetic changes epigenetic or non mutational mechanisms which occur quickly response environmental changes. Normal tissues never develop chemotherapy, because they possess intact machinery. reducing clinical effectiveness, result early termination treatment, reduced relapse free interval survival. There various methods for overcoming these major disadvantages Combination chemotherapy with clear understanding biochemical, molecular pharmacokinetic interaction between individual drugs a given combination method. Optimal scheduling also strategy controlling therapy. Control avenues administration dose intensification provide better outcome. Despite measures overcome resistance, problem especially multidrug still casting its shadow successful A links will open up new circumventing this fundamental prolong life expectancy patient. This article gives an overview encountered