Genotyp- bzw. Phänotyp-basierte Arzeimittelformulierungen

作者: Thomas Eissing , Kristin Dickschen , Stefan Willmann

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摘要: Die Erfindung betrifft eine Kombination aus zweien oder mehreren pharmazeutisch aktiven Substanzen, von denen mindestens ein Stoffwechselprodukt ("Metabolit") der anderen ("Muttersubstanz") ist, insbesondere wobei deren Dosierungen derart gewahlt werden, dass geno- bzw. phanotypisch bedingte Variabilitat Umsetzung Muttersubstanz zu dem Metaboliten in bestimmten Individuen kompensiert wird. Insbesondere ist Metabolit Endoxifen und die Tamoxifen. Eine Formulierung diese beiden Wirkstoffe enthalt wird beansprucht. bezieht sich beispielsweise auf CYP2D6.

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