Mapping DNA structural variation in dogs.

摘要: DNA structural variation (SV) comprises a major portion of genetic diversity, but its biological impact is unclear. We propose that the history and extraordinary phenotypic dogs make them an ideal mammal in which to study effects SV on biology disease. The hundreds existing dog breeds were created by selection extreme morphological behavioral traits. And along with those traits, each breed carries increased risk for different diseases. used array CGH create first map copy number (CNV) or dogs. extent this variation, some gene classes affected, are similar mice humans. Most canine CNVs affect genes, including disease candidate thus likely be functional. identified many may class specific. Cluster analysis CNV regions showed tend group according classes. Our combined findings suggest (1) linkage disequilibrium flanking sequence, (2) associated breed-specific discuss how catalog will accelerate identification basis traits diseases, beginning use whole genome association candidate-CNV/gene approaches.