Hospitalizations for aplastic anemia and agranulocytosis in Saskatchewan: incidence and associations with antecedent prescription drug use.

摘要: A population-based study to estimate the incidence of hospitalizations for aplastic anemia and agranulocytosis evaluate associations between these disorders antecedent prescription drug use was performed using Saskatchewan administrative health care databases. Hospital charts cancer registration data were utilized apply strict diagnostic criteria case identification. Estimates annual 2.7 3.0 per million, which are similar those from other recent studies with comparable identification criteria. Only a small number cases available potential causes, leading an analysis limited power. Nevertheless, significant found tocainide, gold salts, antidepressants; anti-thyroids, trimethoprim-sulfamethoxazole, β-lactams, sulfasalazine, chlorpromazine, carbamazepine, glyburide, procainamide, although antibiotics may indicate response rather than possible cause. These findings generally consistent results case-control investigations.