Microenvironment abnormalities and lymphomagenesis: Immunological aspects

作者: Joseph G. Taylor , John G. Gribben

DOI: 10.1016/J.SEMCANCER.2015.07.004

关键词: Immune systemInterleukin 10Immune toleranceBiologyCD8AntigenCytotoxic T cellImmunologyImmunosurveillanceNKG2D

摘要: Innate and adaptive immune cells within the microenvironment identify eliminate displaying signs of malignant potential. Immunosurveillance effector Natural Killer (NK) Cytotoxic T Lymphocytes (CTL) through germline receptors such as NKG2D in case CTLs, presentation antigen cell receptor. Manipulation immunosurveillance altered tumor-identifying ligand expression or secretion, resistance to cytotoxicity, compromised cytotoxic activity tolerance mechanisms all contribute failure these systems prevent cancer development. This review examines diverse by which alterations can promote lymphomagenesis.

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