作者: Joseph G. Taylor , John G. Gribben
DOI: 10.1016/J.SEMCANCER.2015.07.004
关键词: Immune system 、 Interleukin 10 、 Immune tolerance 、 Biology 、 CD8 、 Antigen 、 Cytotoxic T cell 、 Immunology 、 Immunosurveillance 、 NKG2D
摘要: Innate and adaptive immune cells within the microenvironment identify eliminate displaying signs of malignant potential. Immunosurveillance effector Natural Killer (NK) Cytotoxic T Lymphocytes (CTL) through germline receptors such as NKG2D in case CTLs, presentation antigen cell receptor. Manipulation immunosurveillance altered tumor-identifying ligand expression or secretion, resistance to cytotoxicity, compromised cytotoxic activity tolerance mechanisms all contribute failure these systems prevent cancer development. This review examines diverse by which alterations can promote lymphomagenesis.