1.11 – The Knoevenagel Reaction
作者： Lutz F. Tietze , Uwe Beifuss
DOI: 10.1016/B978-0-08-052349-1.00033-0
关键词: Benzaldehyde 、 Formaldehyde 、 Medicinal chemistry 、 Diethylamine 、 Diethyl malonate 、 Organic chemistry 、 Knoevenagel condensation 、 Piperidine 、 Chemistry 、 Adduct 、 Ethyl acetoacetate
摘要: In 1894 Knoevenagel published a paper in the journal Chemisehe Berichte on reaction of formaldehyde and diethyl malonate presence diethylamine as catalyst.1 He obtained bis adduct (1). Two years later he was able to show that benzaldehyde ethyl acetoacetate piperidine gives (2) at room temperature 0 °C benzylidene-1,3-di- carbonyl (3; Scheme 1).2
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